• Product NameMarimastat(BB-2516)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityMarimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor for MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 with IC50 of 3 nM, 5 nM, 6 nM, 9 nM and 13 nM, respectively. Phase 3.
• Target NameMMP inhibitor
• CAS No. 154039-60-8
• Calculated MW 331.41
• Formulation C15H29N3O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C |r|
  Pathways:Proteases/Proteasome
  Receptor:MMP-1; MMP-14; MMP-2; MMP-7; MMP-9
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 7 mg/mL warmed (21.12 mM) DMSO: 54 mg/mL (162.94 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kim D, et al. Exp Ther Med. 2017 Apr;13(4):1415-1425.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting