• Product NameMCC950(CP-456773)
• Brief DescriptionInhibitors
• Purification99.12%
• Biological ActivityMCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs.
• Target NameNOD inhibitor
• CAS No. 256373-96-3
• Calculated MW 426.46
• Formulation C20H23N2O5SNa
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(O)C1=COC(=C1)S(=O)(=O)N([Na])C(=O)NC1=C2CCCC2=CC2=C1CCC2 |c:7,18,24,26,t:4|
  Pathways:Immunology/Inflammation; NF-κB
  Receptor:NLRP3
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 40 mg/mL (93.79 mM) DMSO: <1 mg/mL Water: 85 mg/mL (199.31 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Coll RC. et al.A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases..Nat Med. 2015 Mar;21(3):248-55. Coll RC1,

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting