• Product NameMI-136
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMI-136 inhibits DHT-induced expression of androgen receptor (AR) target genes.
• Target NameAndrogen Receptor inhibitor
• CAS No. 1628316-74-4
• Calculated MW 470.51
• Formulation C23H21F3N6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:FC(F)(F)CC1=CC2=C(NC3CCN(CC4=CC=C5NC(=CC5=C4)C#N)CC3)N=CN=C2S1 |c:7,20,23,31,33,t:5,15,17|
  Pathways:Endocrinology/Hormones
  Receptor:Androgen Receptor
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 94 mg/mL (199.78 mM) DMSO: 94 mg/mL (199.78 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Borkin D., et al. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). J Med Chem. 2016 Feb 11;59(3):892-913.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting