• Product NameMK-4101
• Brief DescriptionInhibitors
• Purification98.91%
• Biological ActivityMK-4101, a potent inhibitor of the Hedgehog pathway, shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.
• Target NameHedgehog/Smoothened inhibitor
• CAS No. 935273-79-3
• Calculated MW 493.47
• Formulation C24H24F5N5O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1C(C2=CC=CC=C2C(F)(F)F)=NN=C1C34CCC(CC4)(C5=NOC(C6CC(F)(F)C6)=N5)CC3
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Smoothened
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 98 mg/mL (198.59 mM) DMSO: 98 mg/mL (198.59 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Filocamo G, et al. Mol Cancer Ther. 2016, 15(6):1177-89.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting