• Product NameMK-4827(Niraparib) tosylate
• Brief DescriptionInhibitors
• Purification99.87%
• Biological ActivityMK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM.
• Target NamePARP inhibitor
• CAS No. 1038915-73-9
• Calculated MW 492.59
• Formulation C19H20N4OC7H8O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC=C(C=C1)S(O)(=O)=O.NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)[C@@H]1CCCNC1 |r,c:3,5,16,27,29,t:1,14,18,21,25|
  Pathways:Chromatin/Epigenetic; DNA Damage/DNA Repair
  Receptor:PARP1; PARP2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 98 mg/mL (198.94 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang L, et al. Invest New Drugs. 2012, 30(6):2113-20.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting