• Product NameMK-886 (L-663,536)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.
• Target NameCOX antagonist
• CAS No. 118414-82-7
• Calculated MW 472.08
• Formulation C27H34ClNO2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)C1=CC=C2N(CC3=CC=C(Cl)C=C3)C(CC(C)(C)C(O)=O)=C(SC(C)(C)C)C2=C1 |c:14,32,t:3,5,9,11,24|
  Pathways:Immunology/Inflammation; Neuroscience
  Receptor:COX-1; COX-2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 94 mg/mL (199.11 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Koeberle A, et al. Eur J Pharmacol. 2009, 608(1-3):84-90.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting