• Product NameMLN2480
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityMLN2480 is an oral, selective pan-Raf kinase inhibitor in chinical trials.
• Target NameRaf inhibitor
• CAS No. 1096708-71-2
• Calculated MW 506.29
• Formulation C17H12Cl2F3N7O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@@H](NC(=O)C1=C(Cl)C(N)=NC=N1)C1=NC=C(S1)C(=O)NC1=NC=C(Cl)C(=C1)C(F)(F)F |r,c:5,9,11,16,28,t:14,23,25|
  Pathways:MAPK
  Receptor:Raf
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (197.51 mM) DMSO: 100 mg/mL (197.51 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1 Elizabeth Grace Carideo Cunniff, et al. Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC. Journal of Clinical Oncology 31, no. 15_suppl - published online before print.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting