• Product NameNecrosulfonamide
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNecrosulfonamide is a very specific and potent necrosis inhibitor and blocks mixed lineage kinase domain-like protein (MLKL).
• Target NameMLK antagonist
• CAS No. 1360614-48-7
• Calculated MW 461.47
• Formulation C18H15N5O6S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]
  Pathways:MAPK
  Receptor:necrosis(MLKL)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 92 mg/mL (199.36 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Daohong Liao, et al. Med Chem Commun. 2014, 5, 333.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting