• Product NameOICR-9429
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityOICR-9429 is a potent antagonist of the interaction of WDR5 with peptide regions of MLL and Histone 3 and reduces viability of acute myeloid leukemia cells in vitro.
• Target NameJAK antagonist
• CAS No. 1801787-56-3
• Calculated MW 555.59
• Formulation C29H32F3N5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C2=C(C=C(C=C2)C3=CC(=CC=C3)CN4CCOCC4)NC(=O)C5=CNC(=O)C=C5C(F)(F)F
  Pathways:Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
  Receptor:WDR5
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 15 mg/mL (26.99 mM) DMSO: 38 mg/mL (68.39 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Grebien F, et al. Nat Chem Biol. 2015, 11(8):571-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting