• Product NameOlmutinib (HM61713, BI 1482694)
• Brief DescriptionInhibitors
• Purification99.27%
• Biological ActivityOlmutinib is a novel third-generation epidermal growth factor receptor (EGFR) mutation-specific tyrosine kinase inhibitor (TKI). Also a potent inhibitor of Bruton's tyrosine kinase.
• Target NameEGFR inhibitor
• CAS No. 1353550-13-6
• Calculated MW 486.59
• Formulation C26H26N6O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C1=CC=C(NC2=NC(OC3=CC=CC(NC(=O)C=C)=C3)=C3SC=CC3=N2)C=C1 |c:19,26,31,34,37,t:8,10,13,17,28|
  Pathways:Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
  Receptor:EGFR (cell: H1975); EGFR (cell: HCC827)
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 23 mg/mL (47.26 mM) DMSO: 97 mg/mL (199.34 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wang S, et al. J Hematol Oncol. 2016, 9: 34.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting