• Product NameON123300
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityON123300 is a potent and multi-targeted kinase inhibitor with IC50 of 3.9 nM, 5 nM, 26 nM, 26 nM, 9.2 nM and 11nM for CDK4, Ark5, PDGFRβ, FGFR1, RET, and Fyn, respectively.
• Target NameCDK inhibitor
• CAS No. 1357470-29-1
• Calculated MW 429.52
• Formulation C24H27N7O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C1=CC=C(NC2=NC=C3C=C(C#N)C(=O)N(C4CCCC4)C3=N2)C=C1 |c:31,34,t:8,10,13,15,17|
  Pathways:Cell Cycle/Checkpoint
  Receptor:CDK
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 29 mg/mL (67.51 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Perumal D., Dual Targeting of CDK4 and ARK5 Using a Novel Kinase Inhibitor ON123300 Exerts Potent Anticancer Activity against Multiple Myeloma. Cancer Res. 2016 Mar 1;76(5):1225-36.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting