• Product NameORY-1001 (RG-6016)
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityORY-1001 (RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor with IC50 of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
• Target NameHistone Demethylase inhibitor
• CAS No. 1431326-61-2
• Calculated MW 303.27
• Formulation C15H22N22HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.Cl.NC1CCC(CC1)N[C@@H]1C[C@H]1C1=CC=CC=C1 |r,c:15,17,t:13|
  Pathways:Chromatin/Epigenetic
  Receptor:LSD1/KDM1A
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 4 mg/mL warmed (13.18 mM) DMSO: 5 mg/mL (16.48 mM) Water: 61 mg/mL (201.14 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zheng YC., et al. Irreversible LSD1 Inhibitors: Application of Tranylcypromine and Its Derivatives in Cancer Treatment. Curr Top Med Chem.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting