• Product NamePD168393
• Brief DescriptionInhibitors
• Purification99.04%
• Biological ActivityPD168393 is an irreversible EGFR inhibitor with IC50 of 0.70 nM, irreversibly alkylate Cys-773; inactive against insulin, PDGFR, FGFR and PKC.
• Target NameEGFR inhibitor; FGFR inhibitor; IGF-1R inhibitor; PDGFR inhibitor; PKC inhibitor
• CAS No. 194423-15-9
• Calculated MW 369.22
• Formulation C17H13BrN4O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:BrC1=CC(NC2=NC=NC3=CC=C(NC(=O)C=C)C=C23)=CC=C1 |c:7,21,23,t:1,5,9,11,18|
  Pathways:Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors; JAK/STAT signaling
  Receptor:EGFR; FGFR; Insulin Receptor; PDGFR; PKC
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mL DMSO: 74 mg/mL (200.42 mM) Water: <1 mg/mL (<1 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Fry DW,et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting