• Product NamePI-1840
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityPI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor with IC50 of 27 nM with little effects on the other two major proteasome proteolytic activities, trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).
• Target NameProteasome inhibitor
• CAS No. 1401223-22-0
• Calculated MW 394.47
• Formulation C22H26N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCCC1=CC=C(OCC(=O)N(CC2=NC(=NO2)C2=CC=CN=C2)C(C)C)C=C1 |c:15,21,23,29,t:3,5,13,19|
  Pathways:Proteases/Proteasome; Ubiquitination
  Receptor:Chymotrypsin-like proteasome
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 33 mg/mL (83.65 mM)DMSO: 78 mg/mL (197.73 mM)Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ozcan S, et al. J Med Chem. 2013, 56(10), 3783-3805.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting