• Product NamePicropodophyllin (PPP)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPicropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM. Phase 1/2.
• Target NameIGF-1R inhibitor
• CAS No. 477-47-4
• Calculated MW 414.41
• Formulation C22H22O8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:[H][C@]12COC(=O)[C@@]1([H])[C@H](C1=CC(OC)=C(OC)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@@H]2O |r,c:20,31,t:10,14,23,25|
  Pathways:Tyrosine Kinase/Adaptors
  Receptor:IGF-1R
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 1 mg/mL warmed (2.41 mM) DMSO: 82 mg/mL (197.87 mM) warming Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Lemaire M, Fristedt C, Agarwal P, et al. Clin Cancer Res. 2012 Apr 15;18(8):2230-9.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting