• Product NamePIK-III
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPIK-III, which is a selective inhibitor of ?VPS34 enzymatic activity, inhibits autophagy and de novo lipidation of LC3 and leads to the stabilization of autophagy substrates.
• Target NamePI3K inhibitor
• CAS No. 1383716-40-2
• Calculated MW 319.36
• Formulation C17H17N7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:NC1=NC=C(C(CC2CC2)=N1)C1=CC=NC(NC2=CC=NC=C2)=N1 |c:3,10,15,21,23,25,t:1,13,19|
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 63 mg/mL (197.26 mM) DMSO: 63 mg/mL (197.26 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Dowdle WE, et al. Nat Cell Biol. 2014, 16(11):1069-1079.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting