• Product NamePX-478 2HCl
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityPX-478 2HCl is an orally active, and selective hypoxia-inducible factor-1α (HIF-1α) inhibitor. Phase 1.
• Target NameHIF inhibitor
• CAS No. 685898-44-6
• Calculated MW 394.12
• Formulation C13H20Cl4N2O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.Cl.N[C@@H](CC1=CC=C(C=C1)[N+]([O-])(CCCl)CCCl)C(O)=O |r,c:5,7,t:3|
  Pathways:Angiogenesis; Chromatin/Epigenetic
  Receptor:HIF-1α
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 78 mg/mL (197.9 mM) DMSO: 78 mg/mL (197.9 mM) Water: 78 mg/mL (197.9 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhu Y., et al. Inhibition of HIF-1α by PX-478 suppresses tumor growth of esophageal squamous cell cancer in vitro and in vivo. Am J Cancer Res.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting