• Product NameRG-7112
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityRG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor. Phase 1.
• Target NameMdm2 antagonist
• CAS No. 939981-39-2
• Calculated MW 726.28
• Formulation C38H48Cl2N4O4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCOC1=C(C=CC(=C1)C(C)(C)C)C1=N[C@@](C)(C2=CC=C(Cl)C=C2)[C@](C)(N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1)C1=CC=C(Cl)C=C1 |r,c:5,7,23,51,t:3,14,18,20,46,48|
  Pathways:Apoptosis
  Receptor:Mdm2
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 100 mg/mL (137.68 mM) DMSO: 100 mg/mL (137.68 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Veronica Tisato, et al. MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer. Journal of Hematology & Oncology2017

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting