• Product NameSB239063
• Brief DescriptionInhibitors
• Purification99.73%
• Biological ActivitySB239063 is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.
• Target Namep38 MAPK inhibitor
• CAS No. 193551-21-2
• Calculated MW 368.4
• Formulation C20H21FN4O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=NC=CC(=N1)C1=C(N=CN1[C@H]1CC[C@H](O)CC1)C1=CC=C(F)C=C1 |r,c:4,6,11,28,t:2,9,23,25|
  Pathways:MAPK
  Receptor:p38α; p38β
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 7 mg/mL warmed (19.0 mM) DMSO: 60 mg/mL (162.86 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Underwood DC, et al. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting