• Product NameSGI-7079
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySGI-7079 ,a novel selective Axl inhibitor, inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance.
• Target Namec-Met/HGFR inhibitor; c-RET inhibitor; FLT inhibitor; Src inhibitor; TAM Receptor inhibitor
• CAS No. 1239875-86-5
• Calculated MW 455.53
• Formulation C26H26FN7
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN1CCN(CC1)C1=CC=C(NC2=NC3=C(C(C)=CN3)C(=N2)C2=CC(CC#N)=CC=C2)C=C1F |c:18,22,30,32,35,t:8,10,13,15,25|
  Pathways:Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
  Receptor:Met; RET; FLT3; Yes; AXL; Mer
  Boling pt:
  Melting pt:
  Solubility:Ethanol: <1 mg/mLDMSO: 91 mg/mL (199.76 mM)Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Myers SH, et al. J Med Chem. 2016, 59(8):3593-608.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting