• Product NameSivelestat
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySivelestat is a potent and selective inhibitor of neutrophil elastase with IC50 of 44nM. It almost shows no activity at a range of other proteases.
• Target NameSerine Protease inhibitor
• CAS No. 127373-66-4
• Calculated MW 434.46
• Formulation C20H22N2O7S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:injury
  SMILES:CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1C(=O)NCC(O)=O |c:9,11,20,22,t:7,18|
  Pathways:Proteases/Proteasome
  Receptor:neutrophil elastase
  Boling pt:
  Melting pt:
  Solubility:Ethanol: 86 mg/mL (197.94 mM)DMSO: 86 mg/mL (197.94 mM)Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Li G, et al. Int J Mol Med. 2016, 38(3):767-75.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting