• Product NameUNC-2025
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityUNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
• Target NameFLT inhibitor; TAM Receptor inhibitor
• CAS No. 1429881-91-3
• Calculated MW 513.12
• Formulation C28H41ClN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:Cl.CCCCNC1=NC=C2C(=N1)N(C=C2C1=CC=C(CN2CCN(C)CC2)C=C1)C1CC[C@H](O)CC1 |r,c:7,9,13,29,t:5,16,18,@:12|
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FLT3; AXL; Mer; Tyro3
  Boling pt:
  Melting pt:
  Solubility:Ethanol8 mg/mL warming (15.59 mM)DMSO: 25 mg/mL warming (48.72 mM)Water: 100 mg/mL (194.88 mM)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhang W, et al. J Med Chem. 2014, 57(16), 7031-7041.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting