• Product NameVerubecestat (MK-8931)
• Brief DescriptionInhibitors
• Purification96.00%
• Biological ActivityVerubecestat (MK-8931) is a potent and selective beta-secretase inhibitor and BACE1 protein inhibitor or Beta-site APP-cleaving enzyme 1 inhibitor.
• Target NameBACE inhibitor
• CAS No. 1286770-55-5
• Calculated MW 523.43
• Formulation C19H18F5N5O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@]1(CS(=O)(=O)N(C(=N1)N)C)C2=C(C=CC(=C2)NC(=O)C3=NC=C(C=C3)F)F
  Pathways:Neuroscience
  Receptor:BACE1; BACE2
  Boling pt:
  Melting pt:
  Solubility:Ethanol5 mg/mL (9.55 mM)DMSO: 81 mg/mL (154.74 mM)Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Thaisrivongs DA., et al. Synthesis of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer's Disease. Org Lett. 2016 Nov 18;18(22):5780-5783.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting