• Product NameVR23
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityVR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively.
• Target NameCaspase inhibitor; proteasome inhibitor
• CAS No. 1624602-30-7
• Calculated MW 477.88
• Formulation C19H16ClN5O6S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:[O-][N+](=O)C1=CC=C(C(=C1)[N+]([O-])=O)S(=O)(=O)N1CCN(CC1)C1=CC=NC2=CC(Cl)=CC=C12 |c:5,7,25,30,t:3,23,27,32|
  Pathways:Apoptosis; Proteases/Proteasome; Ubiquitination
  Receptor:Caspase-like proteasomes; Chymotrypsin-like proteasomes; Trypsin-like proteasomes
  Boling pt:
  Melting pt:
  Solubility:Ethanol<1 mg/mLDMSO: 31 mg/mL warming (64.86 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pundir S, et al. Cancer Res. 2015, 75(19), 4164-4175.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting