• Product NameWNK463
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityWNK463 is a pan-WNK-kinase inhibitor. It potently inhibits the in vitro kinase activity of all four WNK family members (WNK1, WNK2, WNK3, and WNK4).
• Target NameWnk inhibitor
• CAS No. 2012607-27-9
• Calculated MW 463.46
• Formulation C21H24F3N7O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(C)NC(=O)C1=CN=CN1C2CCN(CC2)C3=NC=C(C=C3)C4=NN=C(O4)C(F)(F)F
  Pathways:Others
  Receptor:WNK
  Boling pt:
  Melting pt:
  Solubility:Ethanol92 mg/mL (198.5 mM) DMSO: 92 mg/mL (198.5 mM) Water: <1 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yamada K, et al. Nat Chem Biol. 2016, 12(11):896-898.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting