• Product NameCD141 Antibody
• Host SpeciesMouse
• ClonalityMonoclonal
• Clone No.2G1
• PurificationProA affinity purified
• ApplicationsWB, IP, IHC, FCM
• Species ReactivityHu, Ms, Rt
• Immunogen Descriptionpeptide
• Alternative Names    AHUS 6 antibody
  AHUS6 antibody
  BDCA 3 antibody
  BDCA3 antibody
  CD 141 antibody
  CD141 antibody
  CD141 antigen antibody
  Fetomodulin antibody
  Thbd antibody
  THPH12 antibody
  THRM antibody
  Thrombomodulin antibody
  TM antibody
  TRBM_HUMAN antibody
  
• Accession No. Swiss-Prot#:P07204
• UniprotP07204
• Gene ID7056;
• Calculated MW 105kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• WB: 1:500-1:1000
  IHC: 1:50-500
  
  IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)
  FC: 1 μg per 1 x 106 cells

Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.

• Western blot analysis of TM expression in non-transfected (A) and human TM transfected (B) 293T whole cell lysates.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting