• Product NameBcl10 Rabbit mAb
• Host SpeciesRecombinant Rabbit
• Clonality Monoclonal antibody
• Clone No.SN74-04
• PurificationProA affinity purified
• ApplicationsWB, ICC/IF, IHC, IP
• Species ReactivityHu
• Immunogen Descriptionrecombinant protein
• Alternative Names    AI132454 antibody
  B cell CLL/lymphoma 10 antibody
  B cell lymphoma/leukemia10 antibody
  B-cell CLL/lymphoma 10 antibody
  B-cell leukemia/lymphoma 10 antibody
  B-cell lymphoma/leukemia 10 antibody
  Bcl 10 antibody
  Bcl-10 antibody
  Bcl10 antibody
  BCL10_HUMAN antibody
  c E10 antibody
  c-E10 antibody
  C81403 antibody
  CARD containing apoptotic signaling protein antibody
  CARD containing molecule enhancing NF kappa B antibody
  CARD containing molecule enhancing NF kB antibody
  CARD containing molecule enhancing NF-kB antibody
  CARD containing molecule enhancing NFkB antibody
  CARD containing proapoptotic protein antibody
  CARD like apoptotic protein antibody
  CARD-containing apoptotic signaling protein antibody
  CARD-containing molecule enhancing NF-kappa-B antibody
  CARD-containing proapoptotic protein antibody
  CARD-like apoptotic protein antibody
  CARMEN antibody
  Caspase recruiting domain containing protein antibody
  caspase-recruiting domain-containing protein antibody
  cCARMEN antibody
  cE 10 antibody
  cE10 antibody
  CED 3/ICH 1 prodomain homologous E10 like regulator antibody
  CED-3/ICH-1 prodomain homologous E10-like regulator antibody
  CED3/ICH1 prodomain homologous E10 like regulator antibody
  Cellular E10 antibody
  Cellular homolog of vCARMEN antibody
  Cellular-E10 antibody
  CIPER antibody
  CLAP antibody
  hCLAP antibody
  Mammalian CARD containing adapter molecule E10 antibody
  Mammalian CARD-containing adapter molecule E10 antibody
  mE 10 antibody
  mE10 antibody
  R-RCD1 antibody
  
• Accession No. Swiss-Prot#:O95999
• UniprotO95999
• Gene ID8915;
• Calculated MW 31 kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• WB: 1:1,000
  IHC: 1:50-1:200
  ICC: 1:50-1:200

Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFκB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.

• Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Bcl10 antibody. Counter stained with hematoxylin.
• ICC staining Bcl10 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
• ICC staining Bcl10 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting