• Product NameBcl-6 Rabbit mAb
• Host SpeciesRecombinant Rabbit
• Clonality Monoclonal antibody
• Clone No.JB18-48
• PurificationProA affinity purified
• ApplicationsWB
• Species ReactivityHu, Ms
• Immunogen DescriptionRecombinant protein
• Alternative Names    B Cell Lymphoma 6 Protein antibody
  B-cell CLL/lymphoma 6 antibody
  B-cell lymphoma 5 protein antibody
  B-cell lymphoma 6 protein transcript antibody
  BCL5 antibody
  BCL6A antibody
  cys-his2 zinc finger transcription factor antibody
  LAZ3 antibody
  lymphoma-associated zinc finger gene on chromosome 3 antibody
  Protein LAZ-3 antibody
  ZBTB27 antibody
  Zinc finger and BTB domain-containing protein 27 antibody
  Zinc Finger Protein 51 antibody
  zinc finger transcription factor BCL6S antibody
  ZNF51 antibody
  
• Accession No. Swiss-Prot#:P41182
• UniprotP41182
• Gene ID604;
• Calculated MW 79 kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• WB: 1:1,000-5,000
  
  
  
  

Bcl-6, a transcriptional repressor, binds Stat recognition-like DNA elements and influences germinal center development and Th1/Th2 differentiation. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions. HDAC- and silent information regulator (SIR)-2-dependent acet-ylation of Bcl-6 causes downregulation of activity by inhibiting the ability of Bcl-6 to recruit complexes containing histone deacetylases (HDACs). Bcl-6 is frequently deregulated in non-Hodgkin's B cell lymphomas. The human BCL6 gene has been shown to encode a protein of 706 amino acids.

• Western blot analysis of Bcl-6 on NIH-3T3 cell lysate using anti-Bcl-6 antibody at 1/500 dilution.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting