• Product NameThrombomodulin Rabbit mAb
• Host SpeciesRecombinant Rabbit
• Clonality Monoclonal antibody
• Clone No.JB48-23
• PurificationProA affinity purified
• ApplicationsWB,IHC,IP
• Species ReactivityHu
• Immunogen DescriptionRecombinant protein
• Alternative Names    AHUS 6 antibody
  AHUS6 antibody
  BDCA 3 antibody
  BDCA3 antibody
  CD 141 antibody
  CD141 antibody
  CD141 antigen antibody
  Fetomodulin antibody
  Thbd antibody
  THPH12 antibody
  THRM antibody
  Thrombomodulin antibody
  TM antibody
  TRBM_HUMAN antibody
  
• Accession No. Swiss-Prot#:P07204
• UniprotP07204
• Gene ID7056;
• Calculated MW 100 kDa
• Formulation 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
• Storage Store at -20˚C

• WB: 1:500-1:2,000
  IHC: 1:50-1:200
  
  IP: 1:10-1:50
  

Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.

• Western blot analysis of Thrombomodulin on A431 cell using anti-Thrombomodulin antibody at 1/500 dilution.
• Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-Thrombomodulin antibody. Counter stained with hematoxylin.
• Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using anti-Thrombomodulin antibody. Counter stained with hematoxylin.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting