Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
[1] "Structure of the human immune interferon gene."Gray P.W., Goeddel D.V.Nature 298:859-863(1982) [PubMed: 6180322] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. [2] "Expression of human immune interferon cDNA in E. coli an