• Product NameHNRNPM Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen Affinity Purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total HNRNPM polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Heterogeneous nuclear ribonucleoprotein M protein (491-730aa)
• Target NameHNRNPM
• Alternative Names    hnRNP M, HNRNPM, HNRPM, NAGR1
• Accession No. Swiss-Prot#: P52272
• UniprotP52272
• Gene ID4670;
• Concentration 1.0mg/mL
• Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

1"Solution structure of the RNA binding domains of heterogeneous nuclear ribonucleoprotein M." RIKEN structural genomics initiative (RSGI)Submitted (OCT-2006). [2]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).

• Immunohistochemical analysis of paraffin-embedded human breast cancer using #42209 at dilution of 1:100.
• Immunohistochemical analysis of paraffin-embedded human colon cancer using #42209 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting