Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
[1]"Homozygous HOXA1 mutations disrupt human brainstem, inner ear, cardiovascular and cognitive development."Tischfield M.A., Bosley T.M., Salih M.A.M., Alorainy I.A., Sener E.C., Nester M.J., Oystreck D.T., Chan W.-M., Andrews C., Erickson R.P., Engle E.C.Nat. Genet. 37:1035-1037(2005). [2]"Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders."Ingram J.L., Stodgell C.J., Hyman S.L., Figlewicz D.A., Weitkamp L.R., Rodier P.M. Teratology 62:393-405(2000). [3]"Retinoic acid induces three newly cloned HOXA1 transcripts in MCF7 breast cancer cells." Chariot A., Moreau L., Senterre G., Sobel M., Castronovo V.Biochem. Biophys. Res. Commun. 215:713-720(1995).
