Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
[1]"Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS."Yoshinaga S.K., Zhang M., Pistillo J., Horan T., Khare S.D., Miner K., Sonnenberg M., Boone T., Brankow D., Dai T., Delaney J., Han H., Hui A., Kohno T., Manoukian R., Whoriskey J.S., Coccia M.A.Int. Immunol. 12:1439-1447(2000). [2]"Identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor." Ling V., Wu P.W., Finnerty H.F., Bean K.M., Spaulding V., Fouser L.A., Leonard J.P., Hunter S.E., Zollner R., Thomas J.L., Miyashiro J.S., Jacobs K.A., Collins M.J. Immunol. 164:1653-1657(2000). [3]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005).
