• Product NameIRAK2 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen Affinity Purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total IRAK2 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Interleukin-1 receptor-associated kinase-like 2 protein(1-270aa)
• Target NameIRAK2
• Alternative Names    Interleukin-1 receptor-associated kinase-like 2, IRAK-2, IRAK2
• Accession No. Swiss-Prot#: O43187
• UniprotO43187
• Gene ID3656;
• Concentration 1.0mg/mL
• Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

[1]Patterns of somatic mutation in human cancer genomes."Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007). [2]Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling."Lin S.-C., Lo Y.-C., Wu H.Nature 465:885-890(2010). [3]IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z.J. Biol. Chem. 274:19403-19410(1999).

• Immunohistochemical analysis of paraffin-embedded human colorectal carcinoma using #42225 at dilution of 1:100.
• Immunohistochemical analysis of paraffin-embedded human liver cancer using #42225 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting