• Product NameKIR2DS4 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen Affinity Purified
• ApplicationsWB IHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total KIR2DS4 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Killer cell immunoglobulin-like receptor 2DS4 protein (22-245aa)
• Target NameKIR2DS4
• Alternative Names    CD158 antigen-like family member I, MHC class I NK cell receptor, Natural killer-associated transcript 8, NKAT-8, P58 natural killer cell receptor clones CL-39/CL-17, p58 NK receptor CL-39/CL-17, CD158i, KIR2DS4, CD158I, KKA3, NKAT8
• Accession No. Swiss-Prot#: P43632
• UniprotP43632
• Gene ID3809;
• Calculated MW 34kd
• Concentration 1.0mg/mL
• Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Storage Store at -20˚C

• Western blotting: 1:500 - 1:1000
  Immunohistochemistry: 1:20 - 1:200

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

[1]"KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C."Graef T., Moesta A.K., Norman P.J., Abi-Rached L., Vago L., Older Aguilar A.M., Gleimer M., Hammond J.A., Guethlein L.A., Bushnell D.A., Robinson P.J., Parham P.J. Exp. Med. 206:2557-2572(2009). [2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004). [3]"Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes." Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M.J. Immunol. 171:5396-5405(2003).

• All lanes:Killer cell immunoglobulin-like receptor 2DS4 antibody at 4ug/ml Lane 1:K562 whole cell lysate Lane 2:jurkat whole cell lysate secondary Goat polyclonal to rabbit at 1/10000 dilution predicted band size :34kDa observed band size :34kDa
• Immunohistochemical analysis of paraffin-embedded human breast cancer using #42230 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting