Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
[1]"Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling." Wang Y., Ho G., Zhang J.J., Nieuwenhuijsen B., Edris W., Chanda P.K., Young K.H. J. Biol. Chem. 277:48325-48332(2002). [2]"RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha." Glick J.L., Meigs T.E., Miron A., Casey P.J. J. Biol. Chem. 273:26008-26013(1998). [3]"RGSZ1 and Ret RGS: two of several splice variants from the gene RGS20." Barker S.A., Wang J., Sierra D.A., Ross E.M. Genomics 78:223-229(2001) .
