Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
[1]Complete sequencing and characterization of 21,243 full-length human cDNAs."Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004). [2]Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor."Hu Y.C., Shyr C.R., Che W., Mu X.M., Kim E., Chang C.J. Biol. Chem. 277:33571-33579(2002). [3]Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A." Lin Y.L., Wang Y.H., Lee H.J.Biochem. Biophys. Res. Commun. 350:430-436(2006).
