Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1 (PubMed:25274305). May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidences are required to confirm this result in vivo (PubMed:11470777).
[1] Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.Bellefroid E.J., Marine J.-C., Ried T., Lecocq P.J., Riviere M., Amemiya C.T., Poncelet D.A., Coulie P.G., de Jong P.J., Szpirer C., Ward D.