• Product NameLeukocyte elastase inhibitor Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Leukocyte elastase inhibitor polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Leukocyte elastase inhibitor protein£¨1-379aa£©
• Target NameLeukocyte elastase inhibitor
• Alternative Names    Monocyte/neutrophil elastase inhibitor, Peptidase inhibitor 2, ELANH2, MNEI, PI2, SERPINB1
• Accession No. Swiss-Prot#: P30740
• UniprotP30740
• Gene ID1992;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracellular inhibitor of granzyme H.

[1]"Identification of SERPINB1 as a physiological inhibitor of human granzyme H." Wang L., Li Q., Wu L., Liu S., Zhang Y., Yang X., Zhu P., Zhang H., Zhang K., Lou J., Liu P., Tong L., Sun F., Fan Z. J. Immunol. 190:1319-1330(2013). [2]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R. Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012). [3]"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011).

• Immunohistochemical analysis of paraffin-embedded human skin using #42321 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting