Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin.
[1]Heterozygous manifestations in female carriers of Mal de Meleda."Mokni M., Charfeddine C., Ben Mously R., Baccouche D., Kaabi B., Ben Osman A., Dellagi K., Abdelhak S.Clin. Genet. 65:244-246(2004). [2]Mal de Meleda (MDM) caused by mutations in the gene for SLURP-1 in patients from Germany, Turkey, Palestine, and the United Arab Emirates."Eckl K.M., Stevens H.P., Lestringant G.G., Westenberger-Treumann M., Traupe H., Hinz B., Frossard P.M., Stadler R., Leigh I.M., Nuernberg P., Reis A., Hennies H.C. Hum. Genet. 112:50-56(2003). [3]Mutations in the gene encoding SLURP-1 in Mal de Meleda."Fischer J., Bouadjar B., Heilig R., Huber M., Lefevre C., Jobard F., Macari F., Bakija-Konsuo A., Ait-Belkacem F., Weissenbach J., Lathrop M., Hohl D., Prud'homme J.-F.Hum. Mol. Genet. 10:875-880(2001).
