Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine.
[1] "Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase."Casero R.A. Jr., Celano P., Ervin SJ., Applegren N.B., Wiest L., Pegg A.E.J. Biol. Chem. 266:810-814(1991) [2] "Cha