• Product NameAcid-sensing ion channel 3 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsWB IHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Acid-sensing ion channel 3 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Acid-sensing ion channel 3 protein
• Target NameAcid-sensing ion channel 3
• Alternative Names    Amiloride-sensitive cation channel 3 Neuronal amiloride-sensitive cation channel 3 Testis sodium channel 1 ASIC3, ACCN3, SLNAC1, TNAC1
• Accession No. Swiss-Prot#: Q9UHC3
• UniprotQ9UHC3
• Gene ID9311;
• Calculated MW 47kd
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• Western blotting: 1:500 - 1:1000
  

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

[1] Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis.Ishibashi K., Marumo F. Biochem. Biophys. Res. Commun. 245:589-593(1998) [2]Identification, functional expression and chromosomal localisation of a sustained human proton-gated

• All lanes :PICK1 antibody at 2ug/ml+mouse brain tissue secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size:47kDa Observed band size:47kDa

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting