• Product NameAngiogenin Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Angiogenin polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Angiogenin protein
• Target NameAngiogenin
• Alternative Names    RNASE5, ANG, Ribonuclease 5
• Accession No. Swiss-Prot#: P03950
• UniprotP03950
• Gene ID283;
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

[1]Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.Kurachi K., Davie EW., Strydom D.J., Riordan J.F., Vallee B.L.Biochemistry 24:5494-5499(1985) [2]Diversifying selection of the tumor-growth promoter angiogenin in primate evol

• Immunohistochemical analysis of paraffin-embedded human liver tissue using #42438 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting