Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
[1] "Structure of the human immune interferon gene." Gray P.W., Goeddel D.V.Nature 298:859-863(1982) [2] "Expression of human immune interferon cDNA in E. coli and monkey cells."Gray P.W., Leung D.W., Pennica D., Yelverton E., Najarian R., Simonsen C.C
