• Product NameKeratin, type I cytoskeletal 18 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationCaprylic Acid Ammonium Sulfate Precipitation purified
• ApplicationsWB IHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total Keratin, type I cytoskeletal 18 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant Human Keratin, type I cytoskeletal 18 chain protein
• Target NameKeratin, type I cytoskeletal 18
• Alternative Names    Cell proliferation-inducing gene 46 protein Cytokeratin-18 Keratin-18 KRT18 CYK18 PIG46
• Accession No. Swiss-Prot#: P05783
• UniprotP05783
• Gene ID3875;
• Calculated MW 48kd
• Formulation Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Storage Store at -20˚C

• Western blotting: 1:500 - 1:1000
  Immunohistochemistry: 1:20 - 1:200

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

[1] Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.Oshima R.G., Millan J.L., Cecena G.Differentiation 33:61-68(1986) [2] Identification of a cell proliferation-inducing gene.Kim J.W.Submi

• All lanes : Keratin, type I cytoskeletal 18 antibody at 2ug/ml Lane 1 : K562 whole cell lysate Lane 2 : HepG2 whole cell lysate Secondary Goat polyclonal to Rabbit IgG at 1/10000 dilution Predicted band size : 48KDa Observed band size:48KDa
• Immunohistochemical analysis of paraffin-emdedded human placenta using #42526 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting