• Product NameHYAL1 Polyclonal Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen Affinity Purified
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous level of total HYAL1 polyclonal antibody.
• Immunogen Typeprotein
• Immunogen DescriptionRecombinant human Hyaluronidase-1 protein (136-435aa)
• Target NameHYAL1
• Alternative Names    Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
• Accession No. Swiss-Prot#: Q12794
• UniprotQ12794
• Gene ID3373;
• Concentration 1.0mg/mL
• Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20 - 1:200

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

[1]"Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX."Triggs-Raine B., Salo T.J., Zhang H., Wicklow B.A., Natowicz M.R.Proc. Natl. Acad. Sci. U.S.A. 96:6296-6300(1999). [2]"Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis." Chao K.L., Muthukumar L., Herzberg O.Biochemistry 46:6911-6920(2007). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project TeamGenome Res. 14:2121-2127(2004).

• Immunohistochemical analysis of paraffin-embedded human endommetrial cancer using #42654 at dilution of 1:100.
• Immunohistochemical analysis of paraffin-embedded human liver using #42654 at dilution of 1:100.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting