Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
[1]"Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes." Majumder P., Choudhury A., Banerjee M., Lahiri A., Bhattacharyya N.P.FEBS J. 274:3886-3899(2007). [2]"Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo." Majumder P., Chattopadhyay B., Sukanya S., Ray T., Banerjee M., Mukhopadhyay D., Bhattacharyya N.P.Biochem. Biophys. Res. Commun. 353:80-85(2007). [3]"Homer1c interacts with Hippi and protects striatal neurons from apoptosis."Sakamoto K., Yoshida S., Ikegami K., Minakami R., Kato A., Udo H., Sugiyama H.Biochem. Biophys. Res. Commun. 352:1-5(2007).
