• Product NameEGLN1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAntigen affinity purification.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total EGLN1 protein.
• Immunogen Typeprotein
• Immunogen DescriptionFusion protein of human EGLN1
• Target NameEGLN1
• Alternative Names    HPH2; PHD2; SM20; ECYT3; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2
• Accession No. Swiss-Prot#: Q9GZT9
  Gene ID: 54583
• UniprotQ9GZT9
• Gene ID54583;
• Concentration 1.3mg/ml
• Formulation Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:20-1:100

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

• Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using #42722 at dilution 1/25.
• Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using #42722 at dilution 1/25.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting