• Product NameRecombinant Human NFKBIE
• Brief DescriptionRecombinant Protein
• Immunogen DescriptionFusion protein corresponding to a region derived from 63-423 amino acids of human nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
• Target NameNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
• Alternative Names    IKBE
• Accession No. Swissprot:O00221
  Gene Accession:BC011676
• UniprotO00221
• Gene ID4794;
• Storage -20~-80˚C, pH 7.6 PBS

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. NFKBIE protein expression is up-regulated following NF-B activation and during myelopoiesis. NFKBIE is able to inhibit NF-B-directed transactivation via cytoplasmic retention of REL proteins. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-B transcription factor complex. The NF-B complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm.

Note: For in vitro research use only, not for diagnostic or therapeutic use. This product is not a medical device.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting