Chemokine (C-X-C motif) ligand 3?(CXCL3) is a small?cytokine?belonging to the CXC?chemokine?family that is also known as?GRO3 oncogene?(GRO3),?GRO protein gamma?(GROg) and?macrophage inflammatory protein-2-beta?(MIP2b). CXCL3 controls?migration?and?adhesion?of?monocytes?and mediates its effects on its target cell by interacting with a cell surface?chemokine receptor?called?CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of?cerebellum.
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